Author

A. Kenneth MacLeod

University of DundeeORCID 0000-0001-6328-1178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Kevin D. ReadiD· 2 shared Alice H. CostainiD· 1 shared Alpha A. LeeiD· 1 shared Amy TavendaleiD· 1 shared Andrew S. MacDonaldiD· 1 shared Andrew Wells· 1 shared Annette von DelftiD· 1 shared Anthony Simon· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPharmacology & Toxicology

Kevin D. ReadORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 27, 2025

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery.

Sarah D. Davey, Josephine Forde-Thomas, Benjamin J. Hulme…·Karl F. Hoffmann

A cytochrome P450 humanised mouse model is used to study Schistosoma mansoni development, schistosomiasis, drug metabolism and drug efficacy.

1 citation

mouseproteomics

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Pharmacology & ToxicologybioRxivPreprintJun 16, 2025

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor

Ed Griffen, D. Fearon, Briana Lynn McGovern…·Annette von Delft

This paper describes the optimization of a SARS-CoV-2 Mpro inhibitor to address genotoxic and metabolic liabilities, leading to improved in vivo efficacy and exposure.

5 citations

mouseexperimental assay

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