Alice H. Costain

Trypanosoma brucei infection remodels the uterine immune environment and drives neuroendocrine dysfunction

This study shows that Trypanosoma brucei infection affects the uterine immune environment and causes neuroendocrine dysfunction in mice, with distinct effects on morphology and inflammation.

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery.

A cytochrome P450 humanised mouse model is used to study Schistosoma mansoni development, schistosomiasis, drug metabolism and drug efficacy.

SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage

This study shows that SOX9 is critical for maintaining granuloma structure and ECM barrier formation in schistosomiasis, which protects the liver from damage.