This study shows that kinetochore proteins in Drosophila and human cells support Golgi assembly and microtubule dynamics in quiescent neural stem cells.

bioRxiv · May 24, 2026 · PreprintNeuroscience

SIK3-HDAC4-Warts Axis Functions as a Gatekeeper of Neural Stem Cell Reactivation in Drosophila

Yang Gao, Amanda Yunn Ee Ng, Jiaen Lin, Hongyan Wang

This study identifies the SIK3-HDAC4-Warts axis as a molecular switch regulating neural stem cell reactivation in Drosophila through SUMOylation, ubiquitination, and Hippo pathway interactions.

bioRxiv · Apr 14, 2026 · PreprintNeuroscience

Astrocytes control quiescent NSC reactivation via GPCR signaling-mediated F-actin remodeling

Kun‐Yang Lin, Mahekta R. Gujar, Jiaen Lin, Wei Yung Ding, Jiawen Huang, Yang Gao, Ye Sing Tan, Xiang Teng, Low Siok Lan Christine, Pakorn Kanchanawong, Yusuke Toyama, Hongyan Wang

This study identifies a GPCR signaling pathway in astrocytes that regulates F-actin remodeling and NSC reactivation through Mrtf nuclear translocation.

Science Advances · Jul 24, 2024Peer-reviewedDevelopmental Biology

Arl2 Associates with Cdk5rap2 to Regulate Cortical Development via Microtubule Organization

Dongliang Ma, Kun‐Yang Lin, Suresh Divya, Jiaen Lin, Mahekta R. Gujar, Htet Yamin Aung, Ye Sing Tan, Yang Gao, Anselm Salvatore Vincent, Teng Chen, Hongyan Wang

This study shows that Arl2 regulates mouse cortical development by promoting microtubule growth through its interaction with Cdk5rap2.

bioRxiv · Jan 16, 2024 · PreprintNeuroscience