Yusuke Toyama

The paper introduces Microdomes, a 3D biology platform that enables shear-free handling and full-spectrum optical imaging of spheroids and organoids.

This study shows that kinetochore proteins in Drosophila and human cells support Golgi assembly and microtubule dynamics in quiescent neural stem cells.

This paper develops a microfluidic platform to study macrophage-adipocyte interactions by overcoming density mismatch, revealing macrophage dynamics in clearing adipocytes and forming Crown-Like Structures.

This study shows that progerin-induced senescent cells are eliminated by normal cells through mechanical competition and JNK/p38-MAPK pathways, while p16-induced senescent cells resist elimination.

This paper develops a method to deliver genes specifically to macrophages in 3D tumor models, altering the tumor microenvironment to reduce tumorigenicity.

This study identifies ARHGAP12 as a regulator of the paracellular leak pathway by suppressing F-actin assembly at tight junctions without affecting ion flux.

This study identifies a GPCR signaling pathway in astrocytes that regulates F-actin remodeling and NSC reactivation through Mrtf nuclear translocation.

The paper shows that Neurexin and Neuroligin adhesion complexes drive axonal arborisation growth without requiring synaptic activity.