Makoto Hayashi

The paper investigates the relationship between STING accumulation and activation in response to chromosome-derived eccDNA, finding they are uncoupled in certain conditions.

This study identifies the BLM DHBN domain and the roles of WRN, MUS81, and GEN1 in mitotic arrest-dependent telomere deprotection, showing TRF2's protective role.

The paper identifies a CPC-shelterin-BTR axis that regulates mitotic telomere deprotection through phosphorylation events and DDR activation.

This study identifies two parallel pathways regulated by WAPL and telomere deprotection that lead to mitotic death in replication stressed human cells.