Anthony J. Cesare

This paper shows that pulsed narmafotinib priming improves chemotherapy response in pancreatic cancer by reducing fibrosis and enhancing treatment efficacy.

The paper shows that nuclear actin and replication stress regulate telomerase recruitment to telomeres via ATR and mTOR, enabling telomere length maintenance in human cells.

The paper shows that Anillin-dependent actin assembly at PML NBs protects genome stability by shielding under-replicated DNA across cell cycles.

This paper identifies SLFN11's role in preventing alternative lengthening of telomeres by eliminating ATRX-deficient cells during telomere crisis, contributing to chemoresistance in cancer.

The paper identifies a CPC-shelterin-BTR axis that regulates mitotic telomere deprotection through phosphorylation events and DDR activation.

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

The paper investigates how chromatin organization influences replication origin activation and fork directionality using multi-omics data from primary and tumor cells.

The paper compares replication stress management in naive and primed pluripotent mouse cells, finding that primed cells use Atr to prevent genomic damage, while naive cells activate Atm and undergo apoptosis.

The paper shows that the newt Pleurodeles waltl maintains telomeres without telomerase, using ALT for whole-organism telomere length preservation.

This study shows BRG1 promotes proliferation in prostate cancer by regulating gene expression related to cell cycle and DNA replication, independent of AR and FOXA1.

The paper investigates how mutant POT1 alleles cause replication stress and telomere fragility, revealing a role for the nuclear pore complex in resolving these defects and telomere repositioning to the nuclear periphery.

This study identifies two parallel pathways regulated by WAPL and telomere deprotection that lead to mitotic death in replication stressed human cells.

The paper investigates telomere-loop dynamics in chromosome end protection using super-resolution microscopy and finds that t-loops act as conformational switches regulating ATM activation independent of telomere fusion.