Noa Lamm

The paper shows that nuclear actin and replication stress regulate telomerase recruitment to telomeres via ATR and mTOR, enabling telomere length maintenance in human cells.

The paper shows that Anillin-dependent actin assembly at PML NBs protects genome stability by shielding under-replicated DNA across cell cycles.

The paper identifies a CPC-shelterin-BTR axis that regulates mitotic telomere deprotection through phosphorylation events and DDR activation.

The paper investigates how chromatin organization influences replication origin activation and fork directionality using multi-omics data from primary and tumor cells.

The paper investigates how mutant POT1 alleles cause replication stress and telomere fragility, revealing a role for the nuclear pore complex in resolving these defects and telomere repositioning to the nuclear periphery.

This study identifies two parallel pathways regulated by WAPL and telomere deprotection that lead to mitotic death in replication stressed human cells.