Author

Madalena Tarsounas

University of OxfordORCID 0000-0002-4273-2870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Christopher J. LordiD· 2 shared Dragomir B. KrasteviD· 2 shared Rebecca A. DaggiD· 2 shared Alvin Wei Tian NgiD· 1 shared André NussenzweigiD· 1 shared Andrea DegasperiiD· 1 shared Andrea PierangeliniiD· 1 shared Andrew N.J. TuttiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Christopher J. LordORCID

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3 papers

Recent·Most cited

Nucleophagy removes cytotoxic trapped PARP1

Gwendoline Hoslett, Sara Tribble, Pauline Lascaux, Stelios Koukouravas, Ignacio Torrecilla, Wei Song, Cynthia X. Hou, Xia Li, Martín González Fernández, Giuliana De Gregoriis, Rebecca A. Dagg, Darragh Patrick O'Brien, Andrea Pierangelini, Thibaud Martial, Alvin Wei Tian Ng, , Kristijan Ramadan

This study identifies nucleophagy as the mechanism by which trapped PARP1 is cleared, showing that inhibiting this process re-sensitizes PARPi-resistant cells to PARPi.

Nature Cell Biology · Jun 1, 2026Peer-reviewedCell Biology

Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implications

Salome Jingchen Zhao, Ching Chiek Koh, Rachel Brough, Dragomir B. Krastev, Veenu Tripathi, Feifei Song, Sheyne S. A. Choi, Daniella Black, Soraya Boushaki, Cherif Badja, Rebecca A. Dagg, Giuseppe Rinaldi, Ping Jing Toong, Andrea Degasperi, Rohit Prakash, , Serena Nik‐Zainal

The paper shows HRd is a continuum with functional and mutational heterogeneity, highlighting the need for refined molecular classification for precision interventions.

bioRxiv · May 29, 2026 · PreprintGenomics

Topologically associating domain boundaries are enriched in early firing origins and restrict replication fork progression

Emilia Puig Lombardi, Madalena Tarsounas

The paper maps replication origin firing and fork progression within TAD boundaries, showing their relationship with CTCF, cohesin, and replication timing.

bioRxiv · Oct 21, 2020 · PreprintGenomics