Chi-Hong Wu

This study shows that Shank3 knockout mice have impaired cortical taste coding flexibility during learning, leading to slower conditioned taste aversion acquisition.

This study identifies bidirectional phosphorylation changes in Shank3 that regulate synaptic scaling up or down in mouse and rat neurons.

This study shows that strong aversive conditioning leads to long-lasting generalized aversion, with synaptic plasticity in different brain layers governing memory persistence and generalization.

This study shows that synaptic scaling is crucial for making associative memories specific, as blocking it leads to generalized aversion and prolonged synaptic strength increases in conditioned taste aversion memory.