Author

Jeffrey R. Cottrell

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

Mark BatheiD· 3 shared Eike‐Christian WamhoffiD· 2 shared Eric DanielsoniD· 2 shared Karen Perez de ArceiD· 2 shared Li Li· 2 shared Aarno V. PalotieiD· 1 shared Andrea Guerrero· 1 shared Anne Elizabeth CarpenteriD· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersNeuroscience

Mark BatheORCID

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Author profile →

5 papers

Recent·Most cited

Perturbations of a causal synaptic molecular network in autism and schizophrenia revealed with multiplexed imaging

Reuven Falkovich, Eric Danielson, Karen Perez de Arce, Eike‐Christian Wamhoff, Jeffrey R. Cottrell, Morgan Sheng, Mark Bathe

The paper uses PRISM to analyze how knocking down 16 autism and schizophrenia genes affects synaptic protein distributions and constructs a causal network model.

bioRxiv · Jul 11, 2022 · PreprintNeuroscience

A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling

Chi-Hong Wu, Vedakumar Tatavarty, Pierre MJ Beltran, Andrea Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A. Carr, Jeffrey R. Cottrell, Gina G. Turrigiano

This study identifies bidirectional phosphorylation changes in Shank3 that regulate synaptic scaling up or down in mouse and rat neurons.

eLife · Apr 26, 2022Peer-reviewedNeuroscience

Molecular diversity of glutamatergic and GABAergic synapses from multiplexed fluorescence imaging

Eric Danielson, Karen Perez de Arce, Beth A. Cimini, Eike‐Christian Wamhoff, Shantanu Singh, Jeffrey R. Cottrell, Anne Elizabeth Carpenter, Mark Bathe

The paper uses multiplexed fluorescence imaging and machine learning to identify synaptic subtypes and examine their changes under activity suppression.

eNeuro · Dec 21, 2020Peer-reviewedNeuroscience

Burden analysis of missense variants in 1,330 disease-associated genes on 3D provides insights into the mutation effects

Sumaiya Iqbal, Jakob Berg Jespersen, Eduardo Pérez‐Palma, Patrick May, David Hoksza, Henrike Heyne, Shehab Sarar Ahmed, Zaara T. Rifat, M. Sohel Rahman, Kasper Lage, Aarno V. Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, Arthur J. Campbell, Dennis Lal

The paper analyzes missense variants in 1,330 disease genes using 3D protein structures to identify mutational hotspots and their functional impact.

bioRxiv · Mar 5, 2020 · PreprintGenetics

Multiplexed confocal and super-resolution fluorescence imaging of cytoskeletal and neuronal synapse proteins

Syuan-Ming Guo, Remi Veneziano, Simon Gordonov, Li Li, Demian Park, Anthony B. Kulesa, Paul C. Blainey, Jeffrey R. Cottrell, Edward S. Boyden, Mark Bathe

The paper introduces PRISM, a method for multiplexed imaging of synaptic proteins, enabling high-throughput quantification of co-expression and nanometer-scale organization.

bioRxiv · Mar 1, 2017 · PreprintBioengineering