Jaime F. Modiano

This study integrates single-cell and spatial transcriptomic data across species to identify conserved and distinct tumor ecosystems in osteosarcoma, revealing canine models as more faithful and highlighting ECM signaling in metastatic lesions.

This paper develops and validates a 3D genomic blood test for diagnosing multiple canine cancers with high sensitivity and specificity.

The paper compares genomic features of canine and human angiosarcoma, finding shared genes and pathways, suggesting dogs as a valuable model for studying this cancer.