Author
Troy A. McEachron
National Cancer InstituteORCID 0000-0003-0695-5783Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 18 mutual co-author links4 papers
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- Cancer BiologybioRxivPreprint
Integrative Single-cell and Spatial Transcriptomic Analysis of Osteosarcoma Reveals Conserved and Distinct Ecosystems Across Sites and Species
Yogesh Budhathoki, Matthew V. Cannon, Troy A. McEachron…·Ryan David Roberts
This study integrates single-cell and spatial transcriptomic data across species to identify conserved and distinct tumor ecosystems in osteosarcoma, revealing canine models as more faithful and highlighting ECM signaling in metastatic lesions.
- Cancer BiologybioRxivPreprint
STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma
Elizabeth P. Young, Christine A. Johnson, Alex Gia Lee…·Alejandro Sweet-Cordero
This study shows that activating the STING pathway in osteosarcoma leads to tumor regression and immune memory, suggesting it as a therapeutic target.
2 citations - Cancer BiologyCancer ResearchPeer-reviewed✦ In-depth digest
Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastases.
Jason Eigenbrood, Nathan W. Wong, Paul W. Mallory…·Troy A. McEachron
Visium profiling of nine pediatric osteosarcoma pulmonary metastases reveals a conserved granuloma-like architecture: inflamed macrophage-rich periphery, collagen capsule, inflammation-poor core, and CXCR4 as candidate target.
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