Carsten Mim

This study shows that the Panx11-89 mutant forms a functional ATP release channel independently of wild-type Panx1, with conserved structure-function features and sensitivity to inhibitors.

This study identifies phosphorylation as a switch that stabilizes Pannexin1 in an ATP-releasing conformation, important for developing disease modulators.

The paper presents an in silico method to classify and identify co-purified protein complexes using cryoEM data, revealing new structures and multiple membrane scaffold protein assembly states.