Structural basis of ATP release and ion selectivity in Pannexin1 channels
Qingyang Zhang, Junjie Wang, Guillaume Gaullier, David Kotol, Cecilia Blikstad, Gerhard Dahl, René Barro-Soria, Carsten Mim
This study identifies phosphorylation as a switch that stabilizes Pannexin1 in an ATP-releasing conformation, important for developing disease modulators.
bioRxiv · Feb 17, 2025 · PreprintBiophysics