David Kotol

This study identifies phosphorylation as a switch that stabilizes Pannexin1 in an ATP-releasing conformation, important for developing disease modulators.

The paper identifies metabolite-protein interactions in the Calvin cycle of cyanobacteria and lithoautotrophic bacteria, revealing species-specific regulation and feed-forward activation mechanisms.

The paper evaluates the impact of different trypsin variants on proteomics experiments across multiple sample types and methods, identifying variations in performance and providing handling recommendations.

The paper identifies secretory pathway differences between HEK293 and CHO cells that improve recombinant protein expression when switching hosts.

The paper investigates the prognostic significance of PKM transcripts in 25 cancers and identifies a prognostic signature in KIRC, revealing functional roles of alternatively spliced PKM transcripts.

The paper maps and characterizes the human secretome by annotating 2,623 predicted secreted proteins and their spatial distribution, using a high-throughput cell factory for recombinant protein production and analysis.