Developmental BiologyDevelopmental CellPeer-reviewed
Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo
Rajini Chandrasegaram, Sara Gottardo, Abhilesh S Dhawanjewar…·Jelle van den Ameele
The paper uses single-molecule FISH to study mtDNA heteroplasmy dynamics in Drosophila and human cells, revealing developmental bottlenecks and selection effects on mutation load.
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