Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo
Rajini Chandrasegaram, Sara Gottardo, Abhilesh S Dhawanjewar, Antony M. Hynes-Allen, Bingxi Gao, Suvagata Roy Chowdhury, Luis Carlos Tábara, Michele Frison, Stavroula Petridi, Patrick Francis Chinnery, Julien Prudent, Hansong Ma, Jelle van den Ameele
The paper uses single-molecule FISH to study mtDNA heteroplasmy dynamics in Drosophila and human cells, revealing developmental bottlenecks and selection effects on mutation load.
Developmental Cell · May 1, 2026Peer-reviewedDevelopmental Biology