Author

Rajini Chandrasegaram

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Abhilesh S DhawanjewariD· 2 shared Antony M. Hynes-Allen· 2 shared Jelle van den AmeeleiD· 2 shared Stavroula PetridiiD· 2 shared Bingxi GaoiD· 1 shared Bryan P. MarzulloiD· 1 shared Bryce A. Wilson· 1 shared Daniel A. TennantiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersDevelopmental Biology

Abhilesh S DhawanjewarORCID

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2 papers

Recent·Most cited

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

Stavroula Petridi, Abhilesh S Dhawanjewar, Dnyanesh Dubal, Rajini Chandrasegaram, Hannah Dickmänken, Navaroshini Bala-Muraly, Bryce A. Wilson, Thomas Eve, Bryan P. Marzullo, Antony M. Hynes-Allen, Scott A. Jones, Martin S. King, Richard Butler, Marco Sciacovelli, Edmund R.S. Kunji, , Jelle van den Ameele

The paper shows that tissue-wide metabolic buffering allows neural stem cells to maintain proliferation despite mitochondrial dysfunction, highlighting the role of tissue heterogeneity in resilience.

bioRxiv · Sep 15, 2026 · PreprintDevelopmental Biology

Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo

Rajini Chandrasegaram, Sara Gottardo, Abhilesh S Dhawanjewar, Antony M. Hynes-Allen, Bingxi Gao, Suvagata Roy Chowdhury, Luis Carlos Tábara, Michele Frison, Stavroula Petridi, Patrick Francis Chinnery, Julien Prudent, Hansong Ma, Jelle van den Ameele

The paper uses single-molecule FISH to study mtDNA heteroplasmy dynamics in Drosophila and human cells, revealing developmental bottlenecks and selection effects on mutation load.

Developmental Cell · May 1, 2026Peer-reviewedDevelopmental Biology