Author

Matthew James Oberley

Caris Life Sciences (United States)ORCID 0000-0001-6419-2513Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexandra E. KovachiD· 1 shared Alyssa OpltiD· 1 shared Amy ChadburniD· 1 shared Andrea R. HagemanniD· 1 shared Angela M. SchabiD· 1 shared Ari M. MelnickiD· 1 shared Bhavneet Binder· 1 shared Brooke E. SandersiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alexandra E. KovachORCID

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3 papers

Recent·Most cited

Cancer BiologyBlood Cancer JournalPeer-reviewedApr 22, 2026

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response

Mikhail Roshal, Isabella Y. Kong, Wikum Dinalankara…·Ethel Cesarman

This study identifies unique transcriptional features of Hodgkin lymphoma HRS cells, including immune evasion mechanisms and an unfolded protein response, distinguishing them from other B-cell lymphomas.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 4, 2025

Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms

Elena Lomonosova, Megan Loeb, Kevin Rodriguez…·Mary Margaret Mullen

The paper identifies COPS5 as a therapeutic target for overcoming platinum resistance in ovarian cancer by inhibiting nucleotide excision repair and interstrand crosslink repair.

DOI 10.1101/2025.08.04.668450

humanbulk RNA-seq

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Genetic & Genomic MedicineJCO Precision OncologyPeer-reviewedSep 1, 2023

Multi-omic characterization reveals a distinct molecular landscape in young-onset pancreatic cancer

Ifeanyichukwu Chinedu Ogobuiro, Yasmine Baca, Jennifer R. Ribeiro…·Jashodeep Datta

This study compares molecular features of young-onset and average-onset pancreatic cancer using multi-omic data, finding distinct mutation patterns and immune profiles with prognostic implications.

23 citations

humanwhole-genome sequencing

𝕏 PostBluesky