Yana Cen

This study shows that combining HSF1 inhibition with Hsp110 inhibitor 2H enhances antifungal activity by increasing proteome instability in fungal pathogens.

This study identifies NARH as a SIRT5 modulator that differentially regulates its desuccinylation and deacetylation activities, providing insights into SIRT5 regulation and a chemical scaffold for activator development.

This study characterizes PfSir2A's biochemical properties and identifies inhibitors, revealing its nucleosome and fatty acid regulation and discovering small molecule inhibitors for antimalarial development.