Emily Boyle

The paper determines the molecular structure of autophagic cargo condensates using cryo-electron tomography and shows how disordered regions influence condensate properties.

This study identifies NARH as a SIRT5 modulator that differentially regulates its desuccinylation and deacetylation activities, providing insights into SIRT5 regulation and a chemical scaffold for activator development.

This study characterizes PfSir2A's biochemical properties and identifies inhibitors, revealing its nucleosome and fatty acid regulation and discovering small molecule inhibitors for antimalarial development.