Giuseppe Andrea Sautto

Design and characterization of broadly protective influenza A(H3N2) vaccine candidates using protein language models

This study designs influenza A(H3N2) vaccine candidates using protein language models and machine learning, showing two candidates provide broad protection against current and drifted strains in mice.

Assessing the affinity spectrum of an antigen-specific memory B cell repertoire by inverted ImmunoSpot

This paper introduces a high-throughput method to assess the affinity distribution of antigen-specific B cells using an adapted ImmunoSpot assay, demonstrating its application in detecting affinity maturation after vaccination.

Delay of innate immune responses following influenza B virus infection affects the development of robust antibody response in ferrets

This study shows that delayed innate immune responses to influenza B virus in ferrets lead to weaker antibody responses compared to influenza A virus.

Generation of antigen-specific paired chain antibody sequences using large language models

This paper introduces MAGE, a model that generates paired human antibody sequences against specific targets, validated against SARS-CoV-2, H5N1, and RSV-A.

Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody

The paper identifies a pan-betacoronavirus antibody that binds the S2 subunit of spike proteins and induces Fc-dependent antiviral responses, offering insights into non-neutralizing antibody protection.