Author

David Merrick

University of PennsylvaniaORCID 0000-0001-6464-2705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Patrick SealeiD· 3 shared Ryan P. CalhouniD· 3 shared Lin LiuiD· 2 shared Sarah TraynoriD· 2 shared Camille E. M Piquet· 1 shared David J. StegeriD· 1 shared Dominic SantoleriiD· 1 shared Josephine M. E. TaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCell Biology

Patrick SealeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 28, 2026

SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease

Karima Drareni, Ryan P. Calhoun, Lan Cheng…·Patrick Seale

This study shows that SOX4 reprograms adipose stromal cells into CAF-like cells in obesity, promoting metabolic disease through TGFβ and MDK signaling.

DOI 10.64898/2026.09.24.754142

mousehuman

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PhysiologyMolecular MetabolismPeer-reviewedJun 18, 2026

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variant

Dominic Santoleri, Sarah Traynor, Ryan P. Calhoun…·Paul M. Titchenell

This study investigates how the GKRP P446L variant affects hepatic lipid and cholesterol metabolism by reducing GCK activity and increasing cholesterol synthesis.

DOI 10.1016/j.molmet.2026.102404

mouseproteomics

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Molecular BiologyScience AdvancesPeer-reviewedJan 3, 2025

Transcriptional regulation of adipocyte lipolysis by IRF2BP2

Yang Chen, Lin Liu, Ryan P. Calhoun…·Patrick Seale

This study identifies IRF2BP2 as a repressor of adipocyte lipolysis, showing its role in regulating lipolysis-related genes and metabolic homeostasis.

4 citations

humanmouse

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