Author

Dominic Santoleri

University of PennsylvaniaORCID 0000-0002-4468-6564Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Paul M. TitchenelliD· 3 shared Jaclyn E. WellesiD· 2 shared Patrick SealeiD· 2 shared Alessandra ChesiiD· 1 shared Andrew D. WellsiD· 1 shared Babette S. ZemeliD· 1 shared Bao Khanh TrangiD· 1 shared Chang JiangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersPhysiology

Paul M. TitchenellORCID

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3 papers

Recent·Most cited

PhysiologyMolecular MetabolismPeer-reviewedJun 18, 2026

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variant

Dominic Santoleri, Sarah Traynor, Ryan P. Calhoun…·Paul M. Titchenell

This study investigates how the GKRP P446L variant affects hepatic lipid and cholesterol metabolism by reducing GCK activity and increasing cholesterol synthesis.

DOI 10.1016/j.molmet.2026.102404

mouseproteomics

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PhysiologybioRxivPreprintMay 14, 2026

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency

Jaclyn E. Welles, James P. Garifallou, Michael V. Gonzalez…·Paul M. Titchenell

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

DOI 10.64898/2026.05.13.723926

mousescRNA-seq

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Genetic & Genomic MedicinemedRxivPreprintJul 18, 2024

Shared and unique chromatin accessibility and 3D functional interactions of substance use disorder loci implicate cell types beyond the brain

Bao Khanh Trang, Alessandra Chesi, Sylvanus Toikumo…·Struan F.A. Grant

This paper identifies shared and unique chromatin accessibility and 3D interactions of SUD loci, implicating non-neural cell types like pancreatic β-cells and showing a causal link between T2D and AUD.

DOI 10.1101/2024.07.18.24310649

humanATAC-seq

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