Claude Desplan

The paper shows that single-locus chromatin memory in Drosophila medulla progenitors allows spatial identity to be faithfully executed or flexibly bypassed during neuronal fate specification.

The paper identifies cell-type-specific enhancers and regulatory codes for neuronal differentiation in Drosophila using single-cell RNA and ATAC sequencing.

The paper quantifies social interactions in ants to show how structured dueling behavior predicts reproductive hierarchy formation.

The paper identifies HCRG1, a peptide that suppresses juvenile hormone to enable reproductive and longevity changes in ants.

The paper shows calcium waves in Drosophila retinal support cells coordinate uniform tissue patterning through gap junction networks and size-dependent mechanical responses.

The paper shows that a long non-coding RNA, Gul, coordinates GABAergic gene expression by interacting with 3'UTR sites of target mRNAs in Drosophila neurons.

The paper links temporal and Notch identity of medulla neurons to their synaptic location and neuropil targeting depth in the adult Drosophila visual system.

The paper identifies the developmental origins of LCNs in Drosophila using single-cell RNA sequencing and shows they arise from four distinct brain regions with different neurogenesis modes.

The paper identifies spatial subdomains in the Drosophila medulla and links patterning mechanisms to terminal selector expression in neuronal types.

The paper shows that spatial patterning in the Drosophila visual system regulates the number of Distal medulla inhibitory interneurons through domain subdivision and morphogenetic signaling.

The paper annotates glial cell types in the Drosophila visual system using scRNA-seq and identifies subcellular mRNA compartmentalization.

The paper uses scRNA-seq to generate cell-type-specific split-GAL4 reagents for Drosophila development, demonstrating their effectiveness in targeting known cell types and identifying novel ones.

The paper identifies a sustained transcription factor code that defines neuronal diversity in Drosophila and shows how modifying this code can convert cell fates in vivo.

Drosophila larval optic lobe single-cell RNA-seq and pseudotime analysis define a near-complete medulla neuroblast temporal transcription factor series, with Eyeless and Dichaete acting as regulatory hubs.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

The paper shows that extrinsic Activin signaling modulates an intrinsic temporal program in Drosophila mushroom body neuroblasts, leading to increased neuronal diversity by affecting the production of beta neurons.

The paper shows how stochastic R7 photoreceptor subtypes in Drosophila are matched with specific deterministic Dm8 target neurons through cell adhesion molecules and competitive interactions.

The paper identifies transcription factors that regulate common terminal neuronal features across different cell types in Drosophila optic lobes using single-cell RNA sequencing and machine learning.

This study uses CRISPR to knock out the Orco gene in ants, showing its role in olfaction, social behavior, and neural plasticity.