Fei Ye

scGSCA analyzes single-cell RNA sequencing data to detect differential gene-set co-expression across phenotypes, identifying pathway changes missed by bulk methods.

This study shows that Tenascin-C enhances Wnt signaling and promotes invasion and metastasis in thyroid cancer through in vitro and in vivo experiments.

The paper identifies tissue-specific DNA methylation biomarkers for cancer risk by integrating genome and epigenome data from the GTEx consortium and GWAS data.