Robert Konrat

The paper develops cost-effective isotope labeling protocols in HEK293 cells for NMR studies of difficult-to-produce human proteins, enabling detailed structural and functional analysis.

The paper uses NMR and quantum mechanical calculations to analyze the streptavidin-biotin interaction, revealing the role of weak non-covalent interactions in its stability.

This paper introduces a novel GR degrader, KH-103, which selectively degrades glucocorticoid receptors and shows improved efficacy over existing inhibitors.

This study demonstrates that BH4 deficiency exacerbates PD-related stressors and that BH4 augmentation protects dopaminergic neurons in multiple models.