Author

Aleksandra L. Ptaszek

University of ViennaORCID 0000-0002-9111-995XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Robert KonratiD· 2 shared Andreas R. HierlemanniD· 1 shared Dominique Paul· 1 shared Erick M. CarreiraiD· 1 shared Filip SaganiD· 1 shared Gerald PlatzeriD· 1 shared Iryna IvanovaiD· 1 shared Johannes BohacekiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiophysics

Robert KonratORCID

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2 papers

Recent·Most cited

From Weak Interactions to Strong Affinity: Deciphering the Streptavidin-Biotin Interaction through NMR and ComputationalAnalysis

Aleksandra L. Ptaszek, Sarah E. Kratzwald, Filip Sagan, Mario Migotti, Pedro A. Sánchez‐Murcia, Robert Konrat, Gerald Platzer

The paper uses NMR and quantum mechanical calculations to analyze the streptavidin-biotin interaction, revealing the role of weak non-covalent interactions in its stability.

The Journal of Physical Chemistry B · May 13, 2025Peer-reviewedBiophysics

Harnessing PROTAC technology to combat stress hormone receptor activation

Mahshid Gazorpak, Karina M. Hugentobler, Dominique Paul, Pierre‐Luc Germain, Miriam Kretschmer, Iryna Ivanova, Selina Frei, Kei H Mathis, Remo Rudolf, Sergio Mompart Barrenechea, Vincent Fischer, Xiaohan Xue, Aleksandra L. Ptaszek, Julian Holzinger, Mattia Privitera, , Katharina Gapp

This paper introduces a novel GR degrader, KH-103, which selectively degrades glucocorticoid receptors and shows improved efficacy over existing inhibitors.

Nature Communications · Dec 9, 2023Peer-reviewedMolecular Biology