Ulaş Işıldak

The paper identifies a decline in phosphatidylcholine synthesis as a driver of mitochondrial aging that can be reversed by dietary interventions in both worms and human cells.

This study evaluates qpAdm's performance on complex admixture histories and stepping-stone landscapes, finding high false discovery rates and suggesting protocol improvements.

This paper shows that f-statistics can be biased when using non-outgroup SNP ascertainment schemes and proposes a pan-African ascertainment approach to reduce bias in population history inference.

The paper examines somatic copy number variant (CNV) frequencies in neurons from Alzheimer's disease patients and healthy controls using low-coverage single-cell whole-genome sequencing, finding slightly higher CNV frequencies in AD patients but no statistically significant differences.

The paper analyzes gene expression in multiple tissues across development and ageing in mice, finding that tissues converge in expression patterns with age, associated with loss of tissue identity.

This study shows that gene expression heterogeneity increases with aging in the human brain and is linked to lifespan regulation and neuronal functions.