Charles J. Duyckaerts

The paper examines somatic copy number variant (CNV) frequencies in neurons from Alzheimer's disease patients and healthy controls using low-coverage single-cell whole-genome sequencing, finding slightly higher CNV frequencies in AD patients but no statistically significant differences.

This study shows that injecting human Alzheimer's brain extracts into mice with amyloid-beta plaques induces tau pathology, memory deficits, and synaptic loss, with neuritic plaques linked to synaptic impairment.

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.