Raphaël Mercier

The paper benchmarks single-cell methods for meiotic recombination mapping in Arabidopsis thaliana and introduces tools to detect crossovers and haplotypes from sparse sequencing data.

This study identifies HEIP1 as a master regulator of crossover formation in mouse meiosis by orchestrating the recruitment of pro-crossover proteins.

This study identifies three factors that suppress meiotic crossovers near centromeres in Arabidopsis and shows that their mutation increases crossover frequency in these regions.

This study identifies molecular components enforcing monopolar kinetochore orientation in meiosis I of Arabidopsis thaliana, showing cohesin, CENP-C, and SPF2 are essential.

This study disrupts anti-crossover mechanisms in Arabidopsis to reveal a universal crossover potential profile across sexes.

This study investigates the role of MutLgamma in meiotic crossover formation in Arabidopsis thaliana, showing it is partially dispensable for ZMM-dependent crossovers and influences resolution of recombination intermediates.

The paper curates and presents a collection of long-read genome assemblies for Arabidopsis thaliana accessions to enhance plant genome research.

The paper introduces a new measure, interference length, to quantify crossover interference and shows it reveals similar patterns across species, suggesting a common mechanism.

This study identifies FIGL1's role in attenuating meiotic interhomolog repair and shows that XRCC2 and ASY1 counteract FIGL1's effects in Arabidopsis.

The paper identifies FIGL1 as a key factor limiting non crossover events in Arabidopsis thaliana meiosis through tetrad sequencing analysis.

The paper maps meiotic crossover landscapes near centromeres in Arabidopsis, showing suppression linked to structural variation and DNA methylation.

The paper identifies HEIP1 as a conserved protein involved in meiotic crossover formation, showing its role in both early and late stages of the class I crossover pathway in Arabidopsis and its presence in mammals.

This study identifies the FIGNL1-FIRRM complex as essential for completing meiotic recombination in mice by regulating RAD51 and DMC1 loading, independent of DNA damage.

The paper identifies FANCC as an anti-CO gene conserved from vertebrates to plants and shows it regulates meiotic recombination with FANCE and FANCF.

The paper directly determines meiotic crossovers in fission yeast S. pombe, confirming the absence of crossover interference and revealing co-variation in CO numbers across chromosomes.

The paper investigates how meiotic crossover patterning is controlled by ZMM proteins and the synaptonemal complex, showing that HEI10 overexpression increases crossovers and reduces interference while maintaining sexual dimorphism, and ZYP1 mutation disrupts the link between axis length and COs.

The paper shows that megabase-scale recombination landscapes in Arabidopsis are independent of sequence divergence and can be predicted by chromatin features.

The paper investigates whether increasing meiotic crossovers in crop species hybrids is possible by mutating orthologs of genes identified in Arabidopsis.

The paper identifies FLIP as a novel partner of FIGL1 that forms a conserved complex regulating meiotic homologous recombination in Arabidopsis and humans.

The paper increases meiotic recombination in Arabidopsis by combining HEI10 overexpression with RECQ4A/RECQ4B mutations, leading to more crossovers and specific recombination patterns.

This study increases meiotic crossover frequency in hybrid plants by disrupting specific pathways, leading to a 7.8-fold increase in genetic map length.