Author

Frédéric Baudat

Centre National de la Recherche ScientifiqueORCID 0000-0003-2415-8366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 2 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Akbar ZainuiD· 2 shared Bernard de MassyiD· 2 shared Julie A. J. ClémentiD· 2 shared Julien JosephiD· 2 shared Adrien AntkowiakiD· 1 shared Anne DebantiD· 1 shared Annie AndrieuxiD· 1 shared Audrey LaurentiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Akbar ZainuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Temporal tuning of actin nucleation by the repurposed DNA repair complex RAD51/fignl1 encodes distinct axon guidance decisions

Samya Zerkoune, Yvrick Zagar, Julie Delaroche, Julia Danicka, Juliette Vougny, Sinthuya Uthayasuthan, Julien Aureille, Fiona Roche, Rhanna Haantjes, Claudia Gomez-Bravo, Sarah Baudet, Éric Denarier, Akbar Zainu, Philippe Bun, Xavier Guillonneau, , Coralie Fassier

The paper shows how RAD51/fignl1, repurposed from DNA repair, controls axon guidance by modulating F-actin nucleation timing and magnitude.

bioRxiv · Oct 18, 2026 · PreprintNeuroscience

Explaining the rapid evolution of mammalian meiotic recombination proteins

Julien Joseph, Paola Montoya, Frédéric Baudat, Aurora Ruiz‐Herrera, Julien Clavel

The paper analyzes evolutionary rates of 100 meiotic recombination proteins across 400 placental mammals, finding that rapid evolution is driven by reduced purifying selection and linked to chromosome pairing proteins in long-lived species.

bioRxiv · Jun 3, 2026 · PreprintEvolutionary Biology

PRDM9 drives the location and rapid evolution of recombination hotspots in salmonids

Marie Raynaud, Paola Sanna, Julien Joseph, Julie A. J. Clément, Yukiko Imai, Jean‐Jacques Lareyre, Audrey Laurent, Nicolas Galtier, Frédéric Baudat, Laurent Duret, Pierre‐Alexandre Gagnaire, Bernard de Massy

This study identifies PRDM9's role in driving recombination hotspots in salmonids, showing rapid evolution and conservation of its function across vertebrates.

PLoS Biology · Jan 6, 2025Peer-reviewedEvolutionary Biology

The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading

Akbar Zainu, Dupaigne Pauline, Soumya Bouchouika, Julien Cau, Julie A. J. Clément, Pauline Auffret, Virginie Ropars, Jean‐Baptiste Charbonnier, Bernard de Massy, Raphaël Mercier, Rajeev Kumar, Frédéric Baudat

This study identifies the FIGNL1-FIRRM complex as essential for completing meiotic recombination in mice by regulating RAD51 and DMC1 loading, independent of DNA damage.

bioRxiv · May 17, 2023 · PreprintGenetics