David Zwicker

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

The paper presents a 3D multi-omic framework to detect and characterize ovarian cancer precursors in fallopian tubes, identifying TP53 mutations in microscopic lesions.

Controlling the Formation of Multiple Condensates in the Synapse

This study uses computational modeling to show that protein concentration and binding strength variations control cluster formation in synapses, with simulations matching experimental data on PSD95 localization.

Interference Length reveals regularity of crossover placement across species

The paper introduces a new measure, interference length, to quantify crossover interference and shows it reveals similar patterns across species, suggesting a common mechanism.

Dual control of meiotic crossover patterning

The paper investigates how meiotic crossover patterning is controlled by ZMM proteins and the synaptonemal complex, showing that HEI10 overexpression increases crossovers and reduces interference while maintaining sexual dimorphism, and ZYP1 mutation disrupts the link between axis length and COs.

Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned

This paper develops a model of primacy coding in olfaction, showing it enables effective odor discrimination and connects receptor properties to system performance.