Savvas N. Savvides

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

This study reveals the structural mechanisms of IL-36R activation by IL-36γ and IL-37 and spesolimab's allosteric antagonism, providing a blueprint for therapeutic targeting.

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

This paper reports the crystal structure of Nictaba, revealing its carbohydrate-binding properties and a novel lectin dimerization mode.

The paper reanalyzes cryo-EM data to reveal a 2:1 stoichiometry of ALK-ALKAL2 complexes, resolving discrepancies with previous structural studies.

This paper introduces EvolveX, a computational pipeline for designing stable single-domain antibodies with high affinity, demonstrating improved binding affinity to human targets.

The paper reports cryo-EM structures of fully assembled IL-12/IL-23 receptor complexes, revealing structural insights and differences in their interactions with receptors.

This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.

This paper designs small, stable proteins that bind to diverse target proteins using only structural information, achieving nanomolar to picomolar affinities.

The paper shows DNA methylation prevents HIF binding, affecting hypoxia responses and tumour immunotolerance.

This study shows that hapln1b, an ECM component, is required for HSC specification in zebrafish by modulating kit signaling and maintaining ECM integrity.

The paper determines the dimeric structure of GspF, an inner-membrane component of the T2SS, showing its role as an adaptor in pseudopilus biogenesis.