Mechanism of receptor assembly via the pleiotropic adipokine Leptin
Alexandra Tsirigotaki, Ann Dansercoer, Koen H. G. Verschueren, Iva Marković, Christoph Pollmann, Maximillian Hafer, Jan Félix, Catherine Birck, Wouter Van Putte, Dominiek Catteeuw, Jan H. Tavernier, J. Fernando Bazán, Jacob Piehler, Savvas N. Savvides, Kenneth Verstraete
This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.
Nature Structural & Molecular Biology · Mar 23, 2023Peer-reviewedMolecular Biology