Michael Martinez

This study improves HDR-mediated gene insertion in mice with PAH deficiency by inhibiting competing DNA repair pathways, achieving transgene integration in 10% of alleles and reducing serum phenylalanine by 70.6%.

This paper corrects a mouse model of phenylketonuria by transplanting Cypor-deficient hepatocytes selected with acetaminophen, achieving stable normalization of blood phenylalanine levels.

This study examines ERVK11q23.3 expression in placental tissues, finding it upregulated in preterm placenta, expressed by trophoblasts, and involved in immune responses linked to preterm birth.