This study improves HDR-mediated gene insertion in mice with PAH deficiency by inhibiting competing DNA repair pathways, achieving transgene integration in 10% of alleles and reducing serum phenylalanine by 70.6%.

bioRxiv · Feb 24, 2025 · PreprintGenomics

Dynamics of replication origin over-activation

Haiqing Fu, Christophe E. Redon, Bhushan L. Thakur, Koichi Utani, Robin Sebastian, Sang‐Min Jang, Jacob Gross, Sara Mosavarpour, Anna B. Marks, Sophie Z. Zhuang, Sarah B. Lazar, Mishal Rao, Shira T. Mencer, Adrian M. Baris, Lőrinc Sándor Pongor, Mirit I. Aladjem

The paper investigates replication origin over-activation in cancer cells and finds two distinct pools of origins are activated under different conditions.

Nature Communications · Jun 8, 2021Peer-reviewedGenomics

BAMscale: quantification of DNA sequencing peaks and generation of scaled coverage tracks

Lőrinc Sándor Pongor, Jacob Gross, Roberto Vera Alvarez, Junko Murai, Sang‐Min Jang, Hongliang Zhang, Christophe E. Redon, Haiqing Fu, Shar-Yin Naomi Huang, Bhushan L. Thakur, Adrian M. Baris, Leonardo Mariño‐Ramírez, David Landsman, Mirit I. Aladjem, Yves G. Pommier

BAMscale processes DNA sequencing datasets to generate normalized peak scores and scaled coverage tracks for visualization.

Epigenetics & Chromatin · Apr 22, 2020Peer-reviewedBioinformatics