Author

Gabriele Todisco

Humanitas UniversityORCID 0000-0001-6583-3829Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

André G. DeslauriersiD· 1 shared Ann-Charlotte BjörklundiD· 1 shared Dimitris C. KanellisiD· 1 shared Eirini P. PapapetrouiD· 1 shared Elli PapaemmanuiliD· 1 shared Eva Hellström‐LindbergiD· 1 shared Francesca FicaraiD· 1 shared Francis BaumgartneriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

André G. DeslauriersORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 8, 2025

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers

Prajwal Chaitanya Boddu, Rahul Roy, Stephan Hütter…·Manoj M. Pillai

This study identifies a shared trans-acting mechanism in splicing factor mutant cancers that drives retained intron (RI) splicing defects through DDR-induced AMPK-AKT imbalance and SRSF1 hypophosphorylation.

DOI 10.1101/2025.10.08.679601

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyLeukemiaPeer-reviewedAug 26, 2025

SF3B1-mutant mis-splicing of UBA1 confers a targetable therapeutic vulnerability through UBA1 inhibition

Jonas Thier, Sophia Hofmann, Katharina Miria Kirchhof…·Vanessa Lundin

This study identifies UBA1 mis-splicing as a therapeutic target in SF3B1-mutant myelodysplastic syndromes, showing that UBA1 inhibition sensitizes these cells to treatment.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky