Eirini P. Papapetrou

Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

This study shows that the developmental stage of hematopoietic stem cells influences leukemic transformation, lineage hierarchy, and therapy response in pediatric leukemia.

Multiomic characterization, early detection, and therapeutic targeting of myeloid sarcoma

This study characterizes myeloid sarcoma through multi-omic profiling, identifies RAS pathway activation as a hallmark, and shows RAS inhibition reduces tumor burden in mouse models.

SF3B1-mutant mis-splicing of UBA1 confers a targetable therapeutic vulnerability through UBA1 inhibition

This study identifies UBA1 mis-splicing as a therapeutic target in SF3B1-mutant myelodysplastic syndromes, showing that UBA1 inhibition sensitizes these cells to treatment.

Mosaic chromosomal alterations in blood are associated with an increased risk of Alzheimer's disease

The paper finds that mosaic chromosomal alterations in blood are associated with increased Alzheimer's disease risk, with variations by ancestry, mCA subtype, APOE ε4 status, and chromosomal location.

Metabolic Adaptations To Acute Glucose Uptake Inhibition Converge Upon Mitochondrial Respiration For Leukemia Cell Survival

This study shows that leukemia cells rely on increased mitochondrial respiration for survival when glucose uptake is acutely inhibited by KL-11743.

Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome

This study uses single-cell multi-omics to map genotype-to-phenotype relationships in VEXAS syndrome, identifying PERK pathway activation as a therapeutic target.