Giovanni Galletti

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

The paper establishes immgenT-CD8 as a comprehensive reference for mouse CD8αβ T cell differentiation states across diverse immunological contexts.

This paper uses a zebrafish model of leprosy to identify interferon and plasminogen signaling as critical for survival in mycobacterial infection, using RNAseq and CRISPR screening.

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

The paper investigates how spatial location influences the functional diversity of memory CD8 T cells by analyzing their transcriptomes in the small intestine.