Author

Maria I. Matias

La Jolla Institute for ImmunologyORCID 0000-0002-2003-0149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Samuel A. MyersiD· 3 shared Alexander Curtis JonesiD· 1 shared Alexander MonelliD· 1 shared Alexandra C. NewtoniD· 1 shared Allison CafferataiD· 1 shared Amin Alborzian Deh SheikhiD· 1 shared Amir FerryiD· 1 shared Ananda W. GoldrathiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

Samuel A. MyersORCID

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3 papers

Recent·Most cited

IL-27 induces a cytotoxic state in CD4+ T cells distinct from the Th1 lineage

Maria I. Matias, Rémi Marrocco, Kyle Magro, Leonardo D. Sanchez Solis, Sabrina Figueroa Buezo, Laura Hinojosa-Gonzalez, Meronia Jabou, Haolin Lu, Erik Ehinger, Gabriel Ascui, Ye Zheng, Ferhat Ay, Chris A. Benedict, Samuel A. Myers

This study identifies IL-27 as an inducer of a distinct CD4+ cytotoxic T cell program that differs from Th1 lineage.

bioRxiv · Sep 14, 2026 · PreprintImmunology

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function

Nicole E. Scharping, Xuezhen Ge, Maria I. Matias, Fulin Jiang, Allison Cafferata, Maximilian Heeg, Alexander Monell, Giovanni Galletti, Kitty P. Cheung, Angelica E. Rock, Nick Thao, Sydnye L. Shuttleworth, Michael A. Bauer, Kennidy K. Takehara, Amir Ferry, , Ananda W. Goldrath

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

Cell · Nov 1, 2025Peer-reviewedImmunology

Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput

Patrick H. Kennedy, Amin Alborzian Deh Sheikh, Matthew Balakar, Alexander Curtis Jones, Meagan E. Olive, Mudra Hegde, Maria I. Matias, Natan Pirete, Rajan A. Burt, Jonathan Ma Levy, Tamia Little, Patrick G. Hogan, David R. Liu, John G. Doench, Alexandra C. Newton, , Samuel A. Myers

The paper uses base editor screens to assess phosphorylation site functionality in T cell activation, identifying novel sites that modulate transcriptional activity and signaling pathways.

bioRxiv · Nov 11, 2023 · PreprintSystems Biology