Xuezhen Ge

This study identifies proteostasis as critical for T cell differentiation potential and tumor-infiltrating lymphocyte function, showing that maintaining E3 ubiquitin ligases improves anti-tumor responses.

This study identifies mitochondrial-derived double-stranded RNA as a source of RNA stress in aged neurons, which activates the ISR through PKR and contributes to neurodegeneration.

This study identifies HAPSTR1 as a HUWE1 substrate that facilitates its nuclear localization, thereby regulating stress signaling pathways and cell proliferation.