Marc Spehr

This study uses molecular dynamics simulations to investigate how extracellular acidification affects the structure and function of HCN2 channels by disrupting hydrogen bond networks involving residue E212.

This study investigates the pH-dependent structural dynamics of neuropeptide Y using NMR and constant pH simulations, revealing pH-induced changes in helical core length and protonation states.

This study shows DNMT1 maintains cortical network stability by regulating PV interneuron function and glial interactions, leading to behavioral changes when disrupted in mice.

This study identifies a cytosolic function of DNMT1 in regulating neuronal morphogenesis through microtubule dynamics and organelle trafficking, independent of its catalytic activity and nuclear localization.

The paper analyzes sex- and strain-specific chemical signals in mouse urine using VNO activity and molecular profiling to understand their discriminatory power and differences between inbred and wild mice.

The paper investigates the firing patterns of mitral cells in neonatal mice and shows that bursting mitral cells contribute to oscillatory coupling between the olfactory bulb and entorhinal cortex.

This study shows that DNMT1 deletion in interneurons reduces age-related loss of cortical interneurons and improves somatomotor performance in mice.

The paper shows that olfactory bulb activity coordinates with entorhinal circuits in neonatal mice through theta bursts and odor exposure.