Author

Riham Ayoubi

Montreal Neurological Institute and HospitalORCID 0000-0001-6633-655XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:database / resource· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Peter Scottt McPhersoniD· 3 shared Thomas M. DurcaniD· 3 shared A.M. EdwardsiD· 2 shared Carl LaflammeiD· 2 shared Edward A. FoniD· 2 shared Harvinder S. VirkiD· 2 shared Ian McDowelliD· 2 shared Maryam FotouhiiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Peter Scottt McPhersonORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 14, 2025

A validated antibody toolbox for ALS research

Riham Ayoubi, Emma J. MacDougall, Ian McDowell…·Carl Laflamme

The paper establishes a validated antibody platform for ALS research, identifying high-quality antibodies and revealing protein expression patterns in neurological cell types.

DOI 10.1101/2025.09.14.676084

humanproteomics

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Molecular BiologyeLifePeer-reviewedOct 5, 2023

✦ In-depth digest

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

Riham Ayoubi, Joël Ryan, Michael Biddle…·Carl Laflamme

Over half of 614 commercial antibodies for 65 human neuroscience proteins failed a knockout-controlled assay, yet most targets had a well-performing antibody; recombinants performed best.

68 citationstop 1%

humanfluorescence / live-cell microscopy

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NeurosciencebioRxivPreprintMay 29, 2023

A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

Armin Bayati, Riham Ayoubi, Adriana Aguila…·Peter Scottt McPherson

The paper shows that combining α-synuclein fibrils with immune challenges causes Lewy body-like inclusions in human dopaminergic neurons, while cortical neurons do not form such inclusions.

3 citations

humanproteomics

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