Hugo Vaysset

The paper identifies SIRanc, a human homolog of bacterial antiphage SIR2 proteins, and shows it mediates innate immunity via the TLR pathway by degrading NAD+.

The paper uses language models to predict novel antiphage defense proteins in Actinomycetota, discovering six new defense systems and over 45,000 uncharacterized protein families.

This study identifies evolutionary links between bacterial IS110 transposons and archaeal/eukaryotic RNA modification systems, suggesting RNA-guided mechanisms evolved from transposon components.

The paper introduces DefenseFinder, a resource for antiphage defense systems, including a web service, wiki, and databases with structure predictions.

This paper predicts phage-bacteria interactions at the strain level using genomic data from Escherichia isolates and shows tailored phage cocktails are more effective.