Jyothishmathi Swaminathan

This study identifies the REST-AKT-SOX2 axis as a key regulator of stem/progenitor identity and Midkine-mediated communication in SHH medulloblastoma, highlighting it as a potential therapeutic target.

The paper shows that REST elevation in cerebellar granule cell progenitors increases chromatin accessibility, alters Grk6 transcript expression, and hyperactivates Cxcr4-Sdf1 signaling, leading to increased cell migration.

EpiSAFARI detects valleys in epigenetic signals to improve functional element annotations, showing high conservation and enrichment in regulatory regions.