Lei Ming Guo

REST elevation-dependent chromatin remodeling and alternative Grk6 transcript synthesis hyperactivates Cxcr4-Sdf1 signaling in cerebellar granule cell progenitors

The paper shows that REST elevation in cerebellar granule cell progenitors increases chromatin accessibility, alters Grk6 transcript expression, and hyperactivates Cxcr4-Sdf1 signaling, leading to increased cell migration.

A Regularized Bayesian Dirichlet-multinomial Regression Model for Integrating Single-cell-level Omics and Patient-level Clinical Study Data

This study introduces a Bayesian Dirichlet-multinomial regression model to integrate single-cell RNA sequencing data with clinical variables, uncovering cell-type-specific associations across three diseases.

Mapping Cell-to-cell Interactions from Spatially Resolved Transcriptomics Data

The paper introduces a Bayesian framework to map cell-cell interactions from spatial transcriptomics data, revealing new biological insights in cancer and immune responses.

An Interpretable Bayesian Clustering Approach with Feature Selection for Analyzing Spatially Resolved Transcriptomics Data

The paper introduces a Bayesian clustering method with feature selection for spatially resolved transcriptomics data, improving accuracy through a zero-inflated negative binomial model and geospatial integration.

Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture

This study establishes co-cultures of embryonic and extraembryonic stem cells to study lineage crosstalk during early mammalian development, revealing growth inhibition of pluripotent cells by extraembryonic endoderm cells.

Molecular Networks and Key Regulators of the Dysregulated Neuronal System in Alzheimer’s Disease

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.