Vidya Gopalakrishnan

REST-AKT-SOX2 axis controls neuronal lineage state and Midkine-mediated communication in SHH-medulloblastoma.

This study identifies the REST-AKT-SOX2 axis as a key regulator of stem/progenitor identity and Midkine-mediated communication in SHH medulloblastoma, highlighting it as a potential therapeutic target.

Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells.

This study identifies Raptor and GLI1 as USP37 substrates, revealing its context-specific roles in medulloblastoma cells as both tumor suppressor and oncogene.

REST elevation-dependent chromatin remodeling and alternative Grk6 transcript synthesis hyperactivates Cxcr4-Sdf1 signaling in cerebellar granule cell progenitors

The paper shows that REST elevation in cerebellar granule cell progenitors increases chromatin accessibility, alters Grk6 transcript expression, and hyperactivates Cxcr4-Sdf1 signaling, leading to increased cell migration.

Labeling Natural Killer cells with superparamagnetic iron oxide nanoparticles for detection by preclinical and clinical-scale magnetic particle imaging

This study labels NK cells with iron oxide nanoparticles and demonstrates their detection using magnetic particle imaging in preclinical and clinical settings.

EpiSAFARI: Sensitive detection of valleys in epigenetic signals for enhancing annotations of functional elements

EpiSAFARI detects valleys in epigenetic signals to improve functional element annotations, showing high conservation and enrichment in regulatory regions.