Author

Mengxu Zhang

Leiden UniversityORCID 0000-0001-6657-0178Unclaimed ORCID profile · follow to get notified of new preprints

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:rat· 1

Frequent Co-Authors

Elizabeth C. M. de LangeiD· 1 shared Ilona M. Vuist· 1 shared Vivi RottschäferiD· 1 shared

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2024-2024 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperPharmacology & Toxicology

Elizabeth C. M. de LangeORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyEuropean Journal of Pharmaceutical SciencesPeer-reviewedAug 22, 2024

Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport

Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange

This study investigates the brain distribution of remoxipride, showing that brain metabolism, not just BBB efflux, affects Kp,uu,BBB values less than 1.

4 citations

ratbulk RNA-seq

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