Author

Elizabeth C. M. de Lange

Leiden UniversityORCID 0000-0001-8303-1117Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:metabolomics· 3 Organism:rat· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Chunyuan YiniD· 3 shared Thomas HankemeieriD· 3 shared Alida S. D. KindtiD· 2 shared Amy C. HarmsiD· 2 shared Alida Kindt· 1 shared Charlotte Nijgh-van Kooij· 1 shared Colette BlachiD· 1 shared Ilona M. Vuist· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersSystems Biology

Chunyuan YinORCID

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4 papers

Recent·Most cited

Systems BiologyFluids and Barriers of the CNSPeer-reviewedMay 9, 2026

Longitudinal Metabolomic Profiling of Biogenic Amines in Plasma and CSF, and Their Correlation, Reveals Sex-Specific and Age Changes in TgF344 Alzheimer's Disease Transgenic and Wildtype Rats

Chunyuan Yin, Imke Nelen, Amy C. Harms…·Elizabeth C. M. de Lange

The paper analyzes longitudinal metabolomic changes of biogenic amines in plasma and CSF of TgF344 AD rats and WT controls, revealing sex- and age-specific differences.

DOI 10.1186/s12987-026-00811-8

ratmetabolomics

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NeuroscienceAlzheimer s Research & TherapyPeer-reviewedJan 7, 2026

Metabolic Alteration in Oxylipins and Endocannabinoids Point to an Important Role for Soluble Epoxide Hydrolase and Inflammation in Alzheimer's Disease - Finding from Alzheimer's Disease Neuroimaging Initiative.

Kamil Borkowski, Chunyuan Yin, Alida Kindt…·the Frontotemporal Lobar Degeneration Neuroimaging Initiative

The paper analyzes metabolites in AD patients to show inflammation and sEH dysregulation, with sex and disease stage differences, and identifies markers of disease progression and cognitive resilience.

5 citationstop 2%

humanmetabolomics

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Systems BiologyMetabolomicsPeer-reviewedDec 1, 2025

Lipidomic Fingerprints Reveal Sex-, Age-, and Disease-Dependent Differences in the TgF344-AD Transgenic Rats

Chunyuan Yin, Alida S. D. Kindt, Amy C. Harms…·Elizabeth C. M. de Lange

The paper identifies age, sex, and disease-dependent lipidomic changes in TgF344-AD rats, showing similarities to human lipid profiles and developing predictive models for AD.

DOI 10.1007/s11306-025-02350-z

ratmetabolomics

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Pharmacology & ToxicologyEuropean Journal of Pharmaceutical SciencesPeer-reviewedAug 22, 2024

Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport

Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange

This study investigates the brain distribution of remoxipride, showing that brain metabolism, not just BBB efflux, affects Kp,uu,BBB values less than 1.

4 citations

ratbulk RNA-seq

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